HRCarrays           

Project 4/2012
Project title: Array structures for prevention, individualized diagnosis and treatment in cancers with high risk of incidence and mortality
Project’s Director: Dr. Sabin Cinca, CSI
Partners:

  • Institute of Oncology Prof.dr. Alex.Trestioreanu Bucharest – coordinator
  • Project’s Director: Dr. Sabin Cinca, CS I
  • National Institute for Research and Development in Microtechnologies – partner 1
  • Project’s Partner Director: Dr. Adina Bragaru, CS III
  • University of Agronomic Sciences and Veterinary Medicine Bucharest – Institute of Comparative Medicine – partner 2
  • Project’s Partner Director: Dr. Emilia Balint

Budget: 2.000.000 lei
Duration: 36 monthes (2012 – 2015)
Abstract:
Cancer is a worldwide health problem and represents a major public health challenge as it is responsible for 25% of all deaths, being the second most common cause of death after cardio-vascular diseases. In considerations of these peculiarities and of the socio-economic impact of the expected rise of cancer, it appears of priority importance to address the prevention, diagnosis and therapy of this disease more effectively. One of the main directions currently pursued for increasing the proportion of positive responses in the treatment of cancer is the attempt to individualize treatment. Investigation of gene expression profiling is a relatively new methodology for characterization of cancer at the molecular level which tends to be a very useful tool because of its potential to improve clinical management of disease. Very surprising in a way, if the knowledge on molecular aspects of human cancer strongly developed in the last 20 – 30 years, much less data exist in respect to animal cancers, yet this one tends to become an important problem, especially for pets.
The main objectives of the project are designing, fabrication, tests and validation of array structures that could be used to details molecular / genetic particularities of two major forms of cancer: breast cancer, and colon cancer, in order to develop new tools for cancer prevention, and for an individualized ways of diagnosis, treatment and prognostic, both in humans and animals. Interest genes will be RAS, for breast cancer (humans and animals) and colon cancer (humans), and BRCA, for breast cancer, in humans and animals and for cancer prevention. Other expected achievements will be: contribution to existing data on molecular characteristics of cancer; comparative studies between humans and animals referring to cancer genes expression; translation of the results in human and animal clinics; identification of risk groups for breast cancer.